| Symbol
| KLK8
| contributors: mct - updated : 16-04-2020
|
| HGNC name
| kallikrein-related peptidase 8
|
| HGNC id
| 6369
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
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| --over
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in skin diseases, such as psoriasis vulgaris, lichen planus, and atopic dermatitis | | tumoral
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| --over
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confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness | | tumoral
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| --over
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in oral squamous cell carcinoma and may be implicated in malignant progression  | | tumoral
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| --over
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in most salivary gland tumors | | constitutional
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| --over
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in skin inflammation increased expression in the stratum spinosum | | constitutional
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| --over
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higher levels of KLK8 in female brain may increase the risk for Alzheimer disease | | tumoral
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| --over
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was correlated with the progression of Colorectal cancer | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| KLK8-T4 alternative splice variant, alone or in combination, may be a new independent marker of unfavorable prognosis in lung cancer | |
can serve as a novel independent biomarker of unfavorable prognosis for Breast cancer patients | |
potential independent prognostic indicator for Colorectal cancer | |
potential biomarker in colon adenocarcinoma | |
potential clinical utility of blood and CSF KLK8 as a biomarker for incipient Alzheimer disease | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| neurology | neurodegenerative | alzheimer | |
| therapeutic potential of KLK8 inhibition by counteracting plasticity deficits in AD-affected brain |
| | |
|
| on stress, neuropsin-deficient mice do not show EphB2 cleavage and its dissociation from NR1 resulting in a static EphB2–NR1 interaction, attenuated induction of the Fkbp5 gene and low anxiety |