SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| actin cytoskeleton |
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at the interface between the lamellipodial actin meshwork and the membrane |
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PRKACA is localized at the leading edge of membrane protrusions and colocalized with WASF2 |
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MAPK1 colocalizes with the WASF2 regulatory complex (WRC) at lamellipodial leading edges and directly phosphorylates two WRC components: WASF2 and ABI1 |
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DIAPH1 and WASF2 synergize with BAIAP2 to form filopodia |
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is a junctional component at the zonula adherens |
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might be retained in the cytoplasm through its association with SKAP2 |
basic FUNCTION
| acting as a potential regulator of actin cytoskeleton and playing a key role in the induction of actin-based processes |
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required for directed cell migration, angiogenesis and cardiovascular development |
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playing a critical role in actin-based processes downstream of Rac that are essential for cell movement |
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implicated in cancer metastasis |
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implicated in the formation of peripheral ruffles and chemotactic migration |
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with DOCK3, NEDD9, ARHGAP22, are key molecules regulating RAC1 and RHO signaling that determine the mode of movement driving melanoma cell metastasis |
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membrane transport of WASF2 implicated in formation of lamellipodia, the first step during cell migration, and involves actin reassembly |
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involved in lamellipodia formation necessary for epithelial cell migration and invasion |
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regulates membrane protrusions and cell migration by promoting Arp2/3 complex-dependent actin reorganization |
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WASF2 and WASL have parallel pathways to F-actin reorganization and function in human NK cells |
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WASF2 is recruited to the zonula adherens (ZA) in response to CDH1 adhesion |
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critical role for WASF2 complex in regulation of cellular signaling and epithelial morphogenesis |
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mediates actin cytoskeletal reorganization and lamellipodia protrusion formation, which are required for cell migration and invasion |
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WAS and WASF2 differ in their dynamics and their associated proteins |