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FLASH GENE
Symbol WASF1 contributors: mct - updated : 05-09-2019
HGNC name WAS protein family, member 1
HGNC id 12732
Corresponding disease
MRD59 mental retardation, autosomal dominant 59
Location 6q21      Physical location : 110.421.021 - 110.501.207
Synonym name
  • protein WAVE-1
  • verprolin homology domain-containing protein 1
  • wiskott-Aldrich syndrome protein family member 1
  • homology of dictyostelium scar 12
  • Synonym symbol(s) WAVE1, SCAR1, KIAA0269, WAVE, FLJ31482
    DNA
    TYPE functioning gene
    STRUCTURE 80.19 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S434 - D6S283 - D6S1692 - D6S301 - D6S447 - PREP - D6S278 - WASF1 - RPL3 - D6S1635 - D6S1594 - FYN - D6S302 - qter
    Authors Gene Map
    RNA
    TRANSCRIPTS type messenger
    text all transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3132 - 559 - 2005 16275905
    11 - 3230 - 559 - 2005 16275905
    9 - 2987 - 559 - 2005 16275905
    10 - 3085 - 559 - 2005 16275905
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivefemale systemovary   
     male systemtestis  lowly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal leucine zipper motif and a highly basic region
  • a C terminal VCA region (verproline homology, cofilin homology and acidic region)
  • a WH2 domain, playing a role in filament nucleation by Arp2/3
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Wasf1 (97.5 pc)
    homolog to murine Wasf1 (98.4 pc)
    Homologene
    FAMILY
  • WAS protein family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microfilament
    text
  • present in dendrites, dendritic spines, and axonal growth cones
  • localizes to the outer mitochondrial membrane, where it has been shown to play a role in the trafficking of mitochondria to the dendritic spine
  • basic FUNCTION
  • regulator of actin reorganization downstream of RAC
  • required for membrane ruffling
  • a possible involvement in the pathogenesis of neuroblastoma
  • thought to be required for lamellipodium and ruffle formation in cells
  • playing a role with its associated proteins in the mid-piece of maturing sperm
  • required for activity-dependent mitochondrial trafficking to dendritic spines and filopodia
  • role for WASF1 as a critical modulator of the innate immune response to severe bacterial infections
  • WASF1 is a maternal reprogramming factor that also has a necessary role in gene activation in development
  • has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks
  • playing a role in mitochondrial movement into dendritic protrusions
  • WAS and WASF1 may both be required to build pseudopods
  • plays a critical role in binding actin to initiate actin polymerization
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell-cycle control
    PATHWAY
    metabolism
    signaling
    a component
  • associating with the Arp2/3 complex, a nucleating core constituent for actin polymerization in vitro
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with arp2/3 (activated by the VCA region)
  • RAPH1 directly binds active RAC1, which regulates a direct interaction between RAPH1 and the WASF1 complex via ABI1
  • WASF1 interacts and colocalizes with APP in the Golgi apparatus
  • is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the BECN1/BCL2 and BECN1/PI3K-&
  • 8546; complex-dependent pathways
  • NCKAP1 is a cell invasion promoter by binding to WASF1, but also a tumor suppress gene that modulates the cell cycle of hepatocellular carcinoma (HCC) cell lines by targeting RB1/TP53 regulation
  • cell & other
    REGULATION
    inhibited by phosphorylated at multiple sites by cyclin-dependent kinase 5 (Cdk5)
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD59
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • independent prognostic factor for epithelial ovarian cancer (EOC), which suggests that it is a novel and crucial predictor for EOC metastasis
  • Therapy target
    ANIMAL & CELL MODELS