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FLASH GENE
Symbol SH3BP1 contributors: mct - updated : 26-11-2020
HGNC name SH3-domain binding protein 1
HGNC id 10824
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of SH3BP1 has recently been shown to associate with the exocyst in cells overexpressing the GAP
  • an SH3 domain
  • RhoGAP domains, which were thought to be inactive toward RhoA, are also found capable of stimulating the GTPase activity of RHOA in a dose-dependent manner
    • HOMOLOGY
    Homologene
    FAMILY RhoGAP family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • new and specific RAC1 GAP that can act in cells to counter RAC1-mediated membrane ruffling
  • partner of the exocyst complex
  • regulates cell migration via its GAP activity upon RAC1
  • SH3BP1 regulates epithelial junction formation
  • is a critical regulator of junction formation and epithelial morphogenesis in cell models derived from different epithelial tissues
  • SH3BP1 complex contains two activities that regulate the actin cytoskeleton: a GAP and a capping activity
  • ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SH3BP1 formed a complex with CGNL1/paracingulin, a junctional adaptor, and CD2AP, a scaffolding protein, and both were required for normal CDC42 signaling and junction formation
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • downregulates RAC1 at the motile-cell front, indicating that RAC1 inactivation in this location, as well as its activation by GEF proteins, is a fundamental requirement for cell motility
  • SH3BP1, a GTPase-activating protein for CDC42 and RAC1, is a regulator of junction assembly and epithelial morphogenesis
  • CDC42 is a functionally important target of SH3BP1
  • identification and characterization of SH3BP1 as a novel downstream effector of SEMA3E-PlexinD1
  • SH3BP1 specifically inactivating RAC1 and its target WASF2 is required for cell motility, thus regarded as an essential regulator of cancer cell metastasis
  • PACSIN2 competitively interacts with COBLL1 or SH3BP1 with a higher affinity for COBLL1
  • reciprocal interactions among COBLL1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical cancer tissues, and is correlated with a shorter overall survival of patients with cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS