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FLASH GENE

Symbol

YWHAG

contributors: mct - updated : 22-09-2018

HGNC name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
HGNC id	12852

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012479 2 - 3779 NP_036611 28.2 247 - -

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Digestive intestine       moderately Lymphoid/Immune lymph node       moderately Nervous brain       highly   nerve       predominantly Reproductive female system breast mammary gland   moderately Urinary kidney       moderately Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to rattus Ywhag (100 pc)
	homolog to murine Ywhag (100 pc)

Homologene

FAMILY

14-3-3 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	acting as an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway
	inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
	acting as a multifunctional regulator
	involved in negative regulation of protein kinase activity
	acting as a protein kinase C inhibitor
	oncogenic activities cooperate with loss of TP53 to promote lung tumorigenesis
	binds strongly to cruciform structures and is crucial for initiating replication
	role for the YWHAG protein in its binding to local DNA structures which are stabilized by DNA supercoiling

CELLULAR PROCESS	cell life, differentiation
	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

text	regulation of synaptic plasticity
	regulation of neuron differentiation

PATHWAY

metabolism

signaling

regulation of signal transduction

a component

forming a molecular complex with HSPD1 and PRNP in the CNS under physiological conditions and this complex might become disintegrated in the pathologic process of prion diseases

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	p38 MAP kinase
	binding to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (which results in the modulation of the activity of the binding partner)
	interacting with RAF1, SSH1 and CRTC2/TORC2
	binding to insulin-like growth factor receptor
	binding to protein kinase C
	YWHAG binds to the MDM4 domain adjacent to CDKN1A binding suggesting that YWHAG may affect MDM4-mediated CDKN1A proteasomal turnover
	YWHAG binds to phosphorylated serines 49 and 218 of RGS18
	YWHAG induction in Class switch DNA recombination (CSR) is enabled by the CXXC1-mediated H3K4me3 enrichment in the promoter, dependent on NFKB1 and sustained by TCF3
	is a binding partner for TRPM4
	TP53 interacted with C-terminal domain of YWHAG and induced YWHAG ubiquitination
	CSNK2A1 interacts at the neuromuscular synapse with RAPSN, RAC1, YWHAG, and DOK7 proteins and phosphorylates the latter two
	YWHAG directly interacts with the kinase domain of CAMKK2 and the region containing the inhibitory phosphorylation site Thr145 within the N-terminal extension

cell & other

REGULATION

repressed by

negatively regulated by TP53 through binding to its promoter and inhibiting its transcription

Other	phosphorylated by various PKC isozymes
	acetylated

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE53

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     common deletion region of Williams-Beuren syndrome (WBS1) tumoral     --over   in human lung cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS