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FLASH GENE

Symbol

SFTPD

contributors: mct - updated : 22-05-2018

HGNC name	surfactant, pulmonary-associated protein D
HGNC id	10803

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	11.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 1299 - 375 - Kobayashi (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung           respiratory tract larynx       Visual eye retina

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a collagen-like region
	carbohydrate recognition domains (CRD)
	a neck domain plus CRD (NCRD)
	a C-type lectin family domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

collectin family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
	plays important roles in lipopolysaccharide (LPS) recognition
	plays diverse and important roles in innate immunity and pulmonary homeostasis (Crouch 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with decorin, a SFTPD-binding protein (decorin core protein binds the collagen-like region of the SFTPD)
	binds the extracellular domains of TLR2 and TLR4 through its CRD by a mechanism different from its binding to PI and LPS
	putative binding motif for OSCAR within the SFTPD collagenous domain, and interaction is a potential therapeutic target in chronic inflammatory diseases of the lung as well as other diseases involving tissue accumulation of SFTPD, infiltration of inflammatory monocytes

cell & other

REGULATION

inhibited by

MPO (Myeloperoxidase-dependent inactivation of surfactant protein D) (Crouch 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Sftpd mutant lacking N-terminal cysteine residues and truncation mutants lacking the N-terminal domains were resistant to the oxidant-induced alterations in disulfide bonding (Crouch 2010)