SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus
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| intracellular,nuclear envelope
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| text
| colocalizing with actin, ezrin in apical microvilli |
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co-localize with AQP9 in the apical membrane of principal cells of the epididymis and the vas deferens |
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predominantly localized near the actin cytoskeleton, thus poising them near the plasma membrane where they function as scaffold  |
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abundantly expressed in the apical membranes of polarized epithelial cells |
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present in the nuclear and perinuclear region in interphase cells |
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in the prophase of mitosis, redistributes to the cytoplasmic region in a phosphorylation dependent manner and during mitosis, co-localizes with protein phosphatase 2A (PP2A) |
| basic FUNCTION
| involved in diverse aspects of epithelial membrane biology and immune synapse formation in T cells |
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estrogen-responsive gene encoding an inhibitory factor for epithelial Na+/H+ exchanger isoform 3 (NHE3) |
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contributing to attach GPCRs such as PTH1R and ADRB2 to the cytoskeleton and reducing their diffusion |
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protein that regulates trafficking of several G protein-coupled receptors |
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stabilizes the PTHR1 at the cell membrane and increases the fraction of receptor at the cell surface |
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PDZ1 phosphorylation may transduce hormonal signals to regulate the function of membrane proteins in epithelial tissues |
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required to organize complexes at the apical membranes of polarized epithelial cells and the regulation of its interactions at the apical membrane thus appears to be a dynamic process that is important for maintaining epithelial-tissue integrity |
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in the renal proximal tubules, have an important role in urate homeostasis by co-regulating urate uptake and efflux through its interactions with SLC22A12 and ABCC4, respectively |
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SLC9A3R1, SLC9A3R2, and PDZK1, modulate CFTR membrane retention, conductivity, and interactions with other transporters |
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PDZ domain-containing protein that interacts with the PDZ-binding motif of both PRKD1 and PRKD2 |
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essential roles of SLC9A3R1 and ezrin in intracellular trafficking in epithelial cells (long-range allosteric regulation of SLC9A3R1 by ezrin enables the membrane-cytoskeleton to assemble protein complexes that control cross-talk and regulate the strength and duration of signaling) |
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involved in the membrane retention, endocytic sorting, and regulation of activity of membrane proteins and, therefore, plays important roles in their expression, membrane localization and functional regulation |
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important regulator of the pathogenesis of breast tumors |
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critical factor that regulates microvilli assembly and whose activity is regulated by signaling pathways and occupation of its PDZ2 domain |
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critical for neointima formation and induces vascular smooth muscle cells proliferation by decreasing S-phase kinase protein stability, thereby accelerating the degradation of the cell cycle inhibitor CDKN1A |
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implicated in cell division via reversible phosphorylation of the protein with cyclin dependent kinase and PP2A in normal cells |
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exerts a major role in potentiating G protein-coupled receptor (GPCR) internalization |
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modular PDZ domain scaffolding protein, coordinating the assembly of an obligate ternary complex with SLC34A1 and the PKA-anchoring protein EZR to facilitate PTH-responsive cAMP signaling events |
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microvillar scaffolding protein, retaining specific proteins in microvilli and necessary for microvillar biogenesis |
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associates with SLC34A2 in enterocytes and regulates SLC34A2 adaptation |
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is required for normal osteoblast differentiation and matrix synthesis, and in its absence, compensatory mechanisms maintain bone mass, but bone strength is reduced |
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roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells |
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adaptor protein required for epithelial morphogenesis, implicated in the progression of various human malignancies |
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role for SLC9A3R1 in ependymal morphogenesis with direct application to the diagnosis of ependymal tumors |
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important role for SLC9A3R1 in the regulation of Planar Cell Polarity (PCP) signaling and the development of functional motile cilia |
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is a PDZ-scaffold protein that was initially identified as an organizer and regulator of transporters and channels at the apical side of epithelia through actin-binding ezrin-moesin-radixin protein |
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important role of SLC3A3R1 in the epithelial-mesenchymal transition (EMT) of non-small-cell lung cancer cells, as well as migration |
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could have a previously unknown function in pregnancy and in the development of human embryos |
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PDZ-scaffold protein initially identified as an organizer and modulator of transporters and channels at the apical side of epithelia via actin-binding ezrin-moesin-radixin proteins |
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played an essential role in regulating liver cancer progression |
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role of SLC9A3R1 gene in the pathogenesis of age-related hearing loss (ARHL) opening new perspectives in terms of diagnosis, prevention and treatment |
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during lactation, SLC9A3R1 is required for the proper expression and apical localization of ATP2B2, which, in turn, contributes to preventing the premature activation of STAT3 and the lysosome-mediated cell death pathway that usually occur only early in mammary involution |
