Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD163 contributors: mct - updated : 26-01-2016
HGNC name CD163 molecule
HGNC id 1631
Location 12p13.31      Physical location : 7.623.411 - 7.656.414
Synonym name
  • macrophage associated antigen
  • CD163 antigen
  • hemoglobin scavenger receptor
  • Synonym symbol(s) MM130, M130
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    GRCC9 12p13.31 likely ortholog of mouse gene rich cluster, C9 gene B7 12p13 B7 gene ENO2 12p13.31 enolase 2, (gamma, neuronal) DRPLA 12p13.31 dentatorubral-pallidoluysian atrophy (atrophin-1) GRCC10 12p13.31 likely ortholog of mouse gene rich cluster, C10 gene PTPN6 12p13.31 protein tyrosine phosphatase, non-receptor type 6 REA 12p13.31 protein tyrosine phosphatase, non-receptor type 6 C2F 12p13 C2f protein LOC390285 12 similar to vav-1 interacting Kruppel-like protein isoform b C1S 12p13.31 complement component 1, s subcomponent C1R 12p13.31 complement component 1, r subcomponent C1RL 12p13.31 complement component 1, r subcomponent-like LOC283314 12p13.31 hypothetical protein LOC283314 RBP5 12p13.2 retinol binding protein 5, cellular CLSTN3 12p13.31 calsyntenin 3 PXR1 12p13.31 peroxisome receptor 1 LOC341392 12p13.31 similar to olfactory specific medium-chain acyl CoA synthetase M160 12p13.31 scavenger receptor cysteine-rich type 1 protein M160 CD163 12p13.3 CD163 antigen LOC390286 12 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) APOBEC1 12p13.2-p13.1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 GDF3 12p13.1 growth differentiation factor 3 LOC338759 12p13.31 STELLA CLECSF11 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 LOC360030 12p13.31 homeobox C14 NANOG 12p13.31 Nanog homeobox SLC2A14 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 4231 125.4 1156 cytoplasmic 2009 18849484
    intron 15
    - splicing - - 1149 extracellular 1999 10403791
  • intron 7
  • a truncated form
  • 17 splicing 4148 - 1121 cytoplasmic 2009 18849484
    - - 3728 - 1121 - 2006 16189277
    intron 5
    - - - - - - 2006 16522161
  • deletion at the start of exon 15 (deleted region contains a PKCalpha phosphorylation site and an amino acid sequence (YREM) that may support efficient receptor endocytosis)
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells progenitor cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leader peptide (40AA)
  • an extra cellular domain of 1003 residues containing nine long type scavenger receptor cysteine-rich (SRCR) domains, with SRCR domain 3 that is an exposed domain and a critical determinant for the calcium-sensitive coupling of haptoglobin
  • a transmembrane segment of 24 residues
  • a cytoplasmic domain of 49 AA
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • scavenger receptor cystein-rich (SRCR) superfamily
  • class B subfamily
  • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in myeloid specific gene expression, signal inducing
  • activation of CD163 on hematopoietic progenitor cells may mediate a stimulatory effect on erythropoiesis
  • adhesion receptor for erythroblasts in erythroblastic islands, and may have a regulatory role during erythropoiesis
  • macrophage receptor for endocytosis of haptoglobin
  • scavenger receptor pathway involved in detoxification and clearance of extracellular hemoglobin (Hb)
  • acting as a receptor for hemoglobin-haptoglobin complexes and to mediate cell-cell interactions between macrophages and developing erythroblasts in erythroblastic islands
  • macrophage receptor for bacteria and during bacterial infection, on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation
  • soluble form of human CD163 is released from the cell surface by proteolysis after oxidative stress or inflammatory stimuli
  • scavenger receptor for haptoglobin-hemoglobin complexes, that is shedded (as sCD163) by inflammatory stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • bind both Gram-positive and -negative bacteria, and a previously identified cell-binding motif in the second scavenger domain of CD163 was sufficient to mediate this binding
  • protein
  • PF4 may promote atherogenesis by suppressing CD163 in macrophages, which are then unable to upregulate the atheroprotective enzyme heme oxygenase-1 in response to hemoglobin
  • ADAM17 mediates ectodomain shedding of the scavenger receptor CD163
  • overexpression of CD163 by macrophages may be involved in the development of preretinal fibrovascular membranes (FVMs)in eyes with proliferative diabetic retinopathy (PDR), partly through periostin production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in acute liver failure significantly correlated with fatal outcome and might be used with other parameters to determine prognosis
    constitutional     --over  
    during the hemorrhagic fever with renal syndrome acute phase were significantly higher in patients than during the convalescent stage and the levels in the healthy controls
    constitutional     --over  
    in monocytes of active Crohn disease (CD) or ulcerative colitis (UC), associated with increased macrophage activation
    constitutional     --over  
    in people with diabetic polyneuropathy, suggesting that inflammation plays a role in the development of neural impairment
    constitutional     --over  
    in gestational diabetes mellitus
    tumoral     --over  
    associated with poor prognosis in patients with ovarian cancer
    constitutional     --over  
    association of elevated sCD163 with organ dysfunction and adverse outcome of critical illness
    constitutional     --over  
    in patients with scleroderma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy
  • soluble CD163 values were significantly higher in bone marrow samples than in the matched blood samples, and is a a novel biomarker in multiple myeloma
  • may have a role as a biomarker of rheumatoid arthritis (RA) activity suggesting that resident macrophages are important for joint destruction
  • Therapy target
    ANIMAL & CELL MODELS