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Symbol CD163 contributors: mct - updated : 26-01-2016
HGNC name CD163 molecule
HGNC id 1631
Location 12p13.31      Physical location : 7.623.411 - 7.656.414
Synonym name
  • macrophage associated antigen
  • CD163 antigen
  • hemoglobin scavenger receptor
  • Synonym symbol(s) MM130, M130
    TYPE functioning gene
    STRUCTURE 33.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    GRCC9 12p13.31 likely ortholog of mouse gene rich cluster, C9 gene B7 12p13 B7 gene ENO2 12p13.31 enolase 2, (gamma, neuronal) DRPLA 12p13.31 dentatorubral-pallidoluysian atrophy (atrophin-1) GRCC10 12p13.31 likely ortholog of mouse gene rich cluster, C10 gene PTPN6 12p13.31 protein tyrosine phosphatase, non-receptor type 6 REA 12p13.31 protein tyrosine phosphatase, non-receptor type 6 C2F 12p13 C2f protein LOC390285 12 similar to vav-1 interacting Kruppel-like protein isoform b C1S 12p13.31 complement component 1, s subcomponent C1R 12p13.31 complement component 1, r subcomponent C1RL 12p13.31 complement component 1, r subcomponent-like LOC283314 12p13.31 hypothetical protein LOC283314 RBP5 12p13.2 retinol binding protein 5, cellular CLSTN3 12p13.31 calsyntenin 3 PXR1 12p13.31 peroxisome receptor 1 LOC341392 12p13.31 similar to olfactory specific medium-chain acyl CoA synthetase M160 12p13.31 scavenger receptor cysteine-rich type 1 protein M160 CD163 12p13.3 CD163 antigen LOC390286 12 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) APOBEC1 12p13.2-p13.1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 GDF3 12p13.1 growth differentiation factor 3 LOC338759 12p13.31 STELLA CLECSF11 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 LOC360030 12p13.31 homeobox C14 NANOG 12p13.31 Nanog homeobox SLC2A14 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 4231 125.4 1156 cytoplasmic 2009 18849484
    intron 15
    - splicing - - 1149 extracellular 1999 10403791
  • intron 7
  • a truncated form
  • 17 splicing 4148 - 1121 cytoplasmic 2009 18849484
    - - 3728 - 1121 - 2006 16189277
    intron 5
    - - - - - - 2006 16522161
  • deletion at the start of exon 15 (deleted region contains a PKCalpha phosphorylation site and an amino acid sequence (YREM) that may support efficient receptor endocytosis)
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    at STAGE
    physiological period embryo
    Text stem cells progenitor cells
  • a leader peptide (40AA)
  • an extra cellular domain of 1003 residues containing nine long type scavenger receptor cysteine-rich (SRCR) domains, with SRCR domain 3 that is an exposed domain and a critical determinant for the calcium-sensitive coupling of haptoglobin
  • a transmembrane segment of 24 residues
  • a cytoplasmic domain of 49 AA
  • conjugated GlycoP
  • scavenger receptor cystein-rich (SRCR) superfamily
  • class B subfamily
  • CATEGORY antigen , receptor membrane
        plasma membrane
    basic FUNCTION
  • involved in myeloid specific gene expression, signal inducing
  • activation of CD163 on hematopoietic progenitor cells may mediate a stimulatory effect on erythropoiesis
  • adhesion receptor for erythroblasts in erythroblastic islands, and may have a regulatory role during erythropoiesis
  • macrophage receptor for endocytosis of haptoglobin
  • scavenger receptor pathway involved in detoxification and clearance of extracellular hemoglobin (Hb)
  • acting as a receptor for hemoglobin-haptoglobin complexes and to mediate cell-cell interactions between macrophages and developing erythroblasts in erythroblastic islands
  • macrophage receptor for bacteria and during bacterial infection, on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation
  • soluble form of human CD163 is released from the cell surface by proteolysis after oxidative stress or inflammatory stimuli
  • scavenger receptor for haptoglobin-hemoglobin complexes, that is shedded (as sCD163) by inflammatory stimuli
    a component
    small molecule other,
  • bind both Gram-positive and -negative bacteria, and a previously identified cell-binding motif in the second scavenger domain of CD163 was sufficient to mediate this binding
  • protein
  • PF4 may promote atherogenesis by suppressing CD163 in macrophages, which are then unable to upregulate the atheroprotective enzyme heme oxygenase-1 in response to hemoglobin
  • ADAM17 mediates ectodomain shedding of the scavenger receptor CD163
  • overexpression of CD163 by macrophages may be involved in the development of preretinal fibrovascular membranes (FVMs)in eyes with proliferative diabetic retinopathy (PDR), partly through periostin production
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in acute liver failure significantly correlated with fatal outcome and might be used with other parameters to determine prognosis
    constitutional     --over  
    during the hemorrhagic fever with renal syndrome acute phase were significantly higher in patients than during the convalescent stage and the levels in the healthy controls
    constitutional     --over  
    in monocytes of active Crohn disease (CD) or ulcerative colitis (UC), associated with increased macrophage activation
    constitutional     --over  
    in people with diabetic polyneuropathy, suggesting that inflammation plays a role in the development of neural impairment
    constitutional     --over  
    in gestational diabetes mellitus
    tumoral     --over  
    associated with poor prognosis in patients with ovarian cancer
    constitutional     --over  
    association of elevated sCD163 with organ dysfunction and adverse outcome of critical illness
    constitutional     --over  
    in patients with scleroderma
    Variant & Polymorphism
    Candidate gene
  • soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy
  • soluble CD163 values were significantly higher in bone marrow samples than in the matched blood samples, and is a a novel biomarker in multiple myeloma
  • may have a role as a biomarker of rheumatoid arthritis (RA) activity suggesting that resident macrophages are important for joint destruction
  • Therapy target