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FLASH GENE
Symbol TACC1 contributors: mct - updated : 07-12-2011
HGNC name transforming, acidic coiled-coil containing protein 1
HGNC id 11522
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal coiled-coil domain, called the TACC domain
    • HOMOLOGY
    Homologene
    FAMILY Transforming Acidic Coiled Coil (TACC) family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localizes diffusely to the midzone spindle in anaphase and strongly to the midbody during cytokinesis, and also relocalizes to the nucleolus in interphase
  • localized in the chromatin-enriched fraction of the nucleus and interacted with Retinoid Acid Receptors (RARA) in the nucleus
    • basic FUNCTION
  • playing an important role in in the evolution of breast cancer and mutiple myeloma
  • possible involvement of this protein in the exit of M phase
  • play a role in normal development and tumorigenesis through interactions with multiple complexes involved in transcription, translation, and centrosomal dynamics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with CHTOG and GAS41
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CHTOG and GAS41
  • interacts preferentially with unliganded nuclear receptors
  • localizes at the midbody during cytokinesis and interacts with and is a substrate of AURKC
    • cell & other
    REGULATION
    Phosphorylated by AURKC on a serine at position 228
    Other regulated in a dynamic manner during embryogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    of FGFR1 or FGFR3, to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS