| motifs/domains
| six calpain cleavage sites: one in the IGD |
|
(interglobular domain), one in the KS (keratan sulfate) region, two |
|
in the CS1 and two in the CS2 region  |
|
a 19 aa signal peptide |
|
an Ig-like V-type (immunoglobulin-like) domain |
|
four Link domains |
|
an EGF-like domain |
|
a C-type lectin domain |
|
a complement regulatory-like Sushi (CCP/SCR) domain |
|
three globular domains (G1, G2 and G3) and a GAG-attachment domain to which multiple chondroitin sulfate and keratan sulfate chains are attached (Aoyama 2009) |
|
a hydrophobic transmembrane segment (TM) |
| SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
|
| intracellular,cytoplasm,organelle,lumen
|
|
| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,organelle,lysosome
|
| text
| being a major component of extracellular matrix of cartilagenous tissues |
|
is initially expressed within the growth plate but is lost during the course of calcification |
|
is a major proteoglycan in the intervertebral disc and end plate |
| basic FUNCTION
| playing a role in the resistance to the compression in cartilage |
|
major proteoglycan of the extracellular matrix in cartilage (Aoyama 2009) |
|
playing a critical role in regulating matrix assembly (Stattin 2010) |
|
plays an important role in the organization of the neural extracellular space by binding and organizing hyaluronan to the cell surface through interactions with link protein and tenascins forming a large aggregated quaternary complex |
|
critical role for perineuronal nets and aggrecan in regulating developmental neural plasticity and in the recover from injury |
|
chondroitin sulfate proteoglycan core protein aggrecan is the major protein constituent of cartilage aside from collagen, and is largely responsible for its distinctive mechanical properties |
|
required both for proper cartilage formation in development and maintenance of mature cartilage |
|
ACAN, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress |
|
a major component of cartilage extracellular matrix |
|
has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival during embryonic limb development |
|
is required for outflow tract (OFT) development and when its expression is reduced this is associated with bicuspid aortic valves (BAV) |
|
ACAN and FBLN1 have likely critical roles in determining the biomechanics of the aorta and their modification with age could underpin age-related aortic stiffening |
