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FLASH GENE

Symbol

SCN11A

contributors: mct/npt - updated : 14-12-2013

HGNC name	sodium channel, voltage-gated, type XI, alpha subunit
HGNC id	10583

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HSAN7

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   would be an appealing target for the development of specific drugs to relieve pain neuromuscular spinal muscular atrophy   activation could therefore serve as a target for modulating axonal regeneration in motoneuron diseases such as SMA in which presynaptic activity of VGCCs is reduced

ANIMAL & CELL MODELS

in Nav1.9-null mice, although the Nav1.9 channel does not contribute to basal pain thresholds, it plays an important role in heat pain hypersensitivity induced by subacute paw inflammation