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FLASH GENE
Symbol SCN11A contributors: mct/npt - updated : 14-12-2013
HGNC name sodium channel, voltage-gated, type XI, alpha subunit
HGNC id 10583
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane domains of homology
  • six alpha helical membrane spanning segments
  • two cytoplasmic loops
    • HOMOLOGY
    Homologene
    FAMILY
  • sodium channel family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • SCN11A protein is preferentially localized in axons and growth cones
    • basic FUNCTION
  • sodium channel voltage-gated resistant to tetrodoxin
  • mediating brain-derived neurotrophic factor (BDNF)-evoked membrane depolarization through the receptor tyrosine kinase NTRK2
  • its sodium channel provides an important link between inflammatory processes and changes in urodynamic properties that occur during urinary bladder inflammation (Ritter 2009)
  • may play a role in different pain conditions, and its signaling might be involved in visceral pain (Leo 2010)
  • modulatory role in the development of cold, but not mechanical allodynia in neuropathic pain conditions (Leo 2010)
  • plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models
  • its function appears to be essential for activity-dependent axon growth, acting upstream of spontaneous Ca(2+) elevation through voltage-gated calcium channels (VGCCs)
  • contributes to expression of persistent Na current in small diameter, nociceptive sensory neurons in dorsal root ganglia and is required for inflammatory pain sensation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSAN7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    would be an appealing target for the development of specific drugs to relieve pain
    neuromuscularspinal muscular atrophy 
    activation could therefore serve as a target for modulating axonal regeneration in motoneuron diseases such as SMA in which presynaptic activity of VGCCs is reduced
    ANIMAL & CELL MODELS
  • in Nav1.9-null mice, although the Nav1.9 channel does not contribute to basal pain thresholds, it plays an important role in heat pain hypersensitivity induced by subacute paw inflammation