Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZNF197

contributors: - updated : 04-09-2006

HGNC name	zinc finger protein 197
HGNC id	12988

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.2-p21.1      Physical location : 44.666.510 - 44.689.962
Synonym name	VHL-associated KRAB-A domain-containing protein
	zinc finger protein 20
Synonym symbol(s)	D3S1363E, ZNF20, P18, VHLaK, ZNF166

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	located in a cluster of zinc finger genes at 3p21
STRUCTURE	16.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D3S1620 - ACAA1 - D3S3687 - D3S3685 - D3S3559 - D3S3564 - ZNF35 - ZNF197 - D3S3582 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ZNF197 - V1 - - 4338 - 1029 - Li ZNF197 - V2 - - 2965 - 267 - Li

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine thyroid       highly Reproductive female system uterus cervix   highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal KRAB (Kruppel-associated box) domain
	a SCAN box, leucine-rich, mediating self-association and oligomerization
	22 tandemly arrayed C2H2-type zinc fingers

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to Drosophila CG6654
	homolog to C.elegans B0524.1

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

may be involved in transcriptional regulation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in some thyroid papillary carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS