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FLASH GENE
Symbol GOSR2 contributors: mct/pgu - updated : 16-09-2020
HGNC name golgi SNAP receptor complex member 2
HGNC id 4431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY Qb-SNARE family of vesicle docking proteins
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • trafficking membrane protein involved in intra Golgi transport
  • transports proteins among the medial- and trans-Golgi compartments
  • Golgi vesicle transport gene
  • essential protein mediating ER-to-Golgi membrane fusion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruits ARF1 to the early Golgi and reveal distinct kinetic cycles for ARF1 at early and late Golgi determined by different sets of ARF regulators and effectors
  • TRAPPC11 and another membrane trafficking protein, GOSR2, implicated in DAG1 hypoglycosylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EPM6A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS