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FLASH GENE
Symbol POLG2 contributors: mct - updated : 20-06-2012
HGNC name polymerase (DNA directed), gamma 2, accessory subunit
HGNC id 9180
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • central zinc binding signature sequence
  • a C terminal leucine zipper motif
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • polymerase (DNA directed) gamma 2, accessory subunit, may be involved in protein biosynthesis
  • mitochondrial polymerase processivity subunit, stimulating the polymerase and exonuclease activities,
    • and increasing the processivity of the enzyme
  • key factor in the organization of mitochondrial DNA in multigenomic nucleoprotein complexes
  • exhibits a catalytic subunit- and substrate DNA-dependent dimerization
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text mitochondrial
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds asymetrically to the catalytic subunit where each monomer of the homodimeric accessory subunit plays a distinct role in conferring processivity on POLG1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PEO4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Gene-silencing increased nucleoid numbers
    constitutional     --over  
    over-expression of POLG2 reduced the number and increased the size of mitochondrial nucleoids
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • rs17650301 is a good candidate marker for urinary bladder cancer invasiveness
    • Therapy target
    ANIMAL & CELL MODELS