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FLASH GENE

Symbol

POLG2

contributors: mct - updated : 20-06-2012

HGNC name	polymerase (DNA directed), gamma 2, accessory subunit
HGNC id	9180

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         mouth tongue     highly Nervous brain         Reproductive female system uterus cervix   highly   male system testis       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	central zinc binding signature sequence
	a C terminal leucine zipper motif

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	polymerase (DNA directed) gamma 2, accessory subunit, may be involved in protein biosynthesis
	mitochondrial polymerase processivity subunit, stimulating the polymerase and exonuclease activities,
	and increasing the processivity of the enzyme
	key factor in the organization of mitochondrial DNA in multigenomic nucleoprotein complexes
	exhibits a catalytic subunit- and substrate DNA-dependent dimerization

CELLULAR PROCESS

nucleotide, replication

PHYSIOLOGICAL PROCESS

text	mitochondrial

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds asymetrically to the catalytic subunit where each monomer of the homodimeric accessory subunit plays a distinct role in conferring processivity on POLG1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PEO4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         Gene-silencing increased nucleoid numbers constitutional     --over   over-expression of POLG2 reduced the number and increased the size of mitochondrial nucleoids

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	rs17650301 is a good candidate marker for urinary bladder cancer invasiveness
Therapy target

ANIMAL & CELL MODELS