basic FUNCTION
| acting as an inhibitory regulator of the Ras-cAMP pathway |
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may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity |
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GAP that uses a second domain for catalytic activity, thus pointing to a new function of C2 domains (Pena 2008) |
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prominent Ras/Rap GTPase-activating protein in the postsynaptic density, regulates the timing of spine formation and trafficking of glutamate receptors in cultured neurons (Carlisle 2008) |
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regulates the actin cytoskeleton and & |
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945;-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor insertion through Ras-related pathways (Hamdan 2009) |
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involved in steady-state regulation of actin in mature spines (Carlisle 2008) |
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SYNGAP1 is an important regulator of neuropeptide release from primary sensory neurons and can modulate capsaicin-induced hypernociception |
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plays a unique role in regulating specific downstream intracellular events in response to N-methyl-D-aspartate receptor (NMDAR) activation |
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SYNGAP1-mediated signaling appears to be critical for the proper integration and survival of newborn neurons |
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acts as a critical developmental repressor of neural excitability that promotes the development of life-long cognitive abilities |
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a critical period of SYNGAP1 protein function exists in the first two weeks of hippocampal development, where this protein plays a key role in determining the rate of dendritic spine synapse development |
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plays a critical role in GABAergic circuit function, suggesting that SYNGAP1 haploinsufficiency in GABAergic circuits may contribute to cognitive deficits |
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is a neuronal RAS and Rap GTPase-activating protein with important roles in regulating excitatory synaptic plasticity |