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FLASH GENE

Symbol

MAP3K13

contributors: - updated : 15-11-2006

HGNC name	mitogen-activated protein kinase kinase kinase 13
HGNC id	6852

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	N terminal kinase catalytic domain, hybrid between those of serine/threonine and tyrosine protein kinases,
	a double leucine zipper domain
	a C terminal SSEEEEGEVDSEVE sequence

conjugated

PhosphoP

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

mixed lineage kinase family, serine/threonine protein kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	associated with membrane components

basic FUNCTION

activating the jun N-terminal pathway through activation of the map kinase kinase MAP2K7

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

JNK cascade

a component

dimerizing through its dual leucine-zipper motif

INTERACTION

DNA

RNA

small molecule	cofactor,
	magnesium

protein	interacts with the c-terminus of MAPK8IP1 through the kinase catalytic domain
	binds PRDX3
	associates with the IKK complex through the kinase domain

cell & other

REGULATION

activated by

phosphorylation

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS