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FLASH GENE
Symbol AGAP2 contributors: mct - updated : 08-04-2015
HGNC name ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
HGNC id 16921
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding site motif A (P loop)
  • a pleckstrin homology domain (PH)
  • two ankyrin repeats
  • a proline-rich extension
  • one ARF-GAP domain
  • GTPase-like domain having broader trinucleotide specificity
    • HOMOLOGY
    Homologene
    FAMILY
  • RAS superfamily
  • centaurin gamma-like family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • small GTPase mediating PI3K related Arf signalling
  • isoform PIKE-L acting as an important mediator of merlin grotwth suppression
  • ARF GTPase-activating protein that regulates endosomal trafficking and is overexpressed in different human cancers
  • critical function for AGAP2 in mediating prolactin functions
  • ARF1 and AGAP2 have key trafficking functions at the interface between early endosomes and the TGN
  • has a critical role in EGF-induced squamous cell carcinoma cell proliferation and may function as a proto-oncogene in squamous cell carcinoma
  • GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and AKT1 in the central nervous system (CNS)
  • plays a role in the signalling and recycling of beta2-adrenergic receptors
  • plays pivotal roles to advance Oligodendrocyte (OL) development and myelinogenesis through AKT1/MTOR activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formed a complex with ARRB1 and ARRB2, proteins that are known to regulate beta2-adrenergic receptor signalling and trafficking
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTK2 binds the pleckstrin homology domain of AGAP2, and the binding is independent of PTK2 activation following epidermal growth factor receptor stimulation
  • activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking
  • AGAP1 and AGAP2 can bind to RHOA
  • binding NF2 and inhibition of PI3-kinase activity
  • functional interaction between FYN, AGAP2, and STAT5A in mediating adipogenesis
  • AGAP2 is a novel GNB2L1-interacting protein
    • cell & other
    REGULATION
    Other allosterically regulated through protein binding to the GLD domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pike-/- mice displayed a severe lactation defect that was characterized by enhanced apoptosis and impaired proliferation of mammary epithelial cells