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FLASH GENE

Symbol

RNF144A

contributors: mct - updated : 28-12-2021

HGNC name	ring finger protein 144A
HGNC id	20457

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p25.1      Physical location : 7.057.522 - 7.184.307
Synonym name	likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting protein 4
	ring finger protein 144
	UbcM4-interacting protein 4
	probable E3 ubiquitin-protein ligase RNF144A
Synonym symbol(s)	KIAA0161, UBCE7IP4, RNF144, UIP4, hUIP4
EC.number	6.3.2.-/2.3.2.31

DNA

TYPE	functioning gene
STRUCTURE	158.96 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001349184 9 - 5570 NP_001336113 32 292 - 2020 32557973 NM_001349185 10 - 2527 NP_001336114 - 268 - 2020 32557973 NM_001349181 10 - 2709 NP_001336110 - 318 - 2020 32557973 NM_014746 9 - 5720 NP_055561 32 292 - 2020 32557973 NM_001349186 8 - 5574 NP_001336115 - 209 - 2020 32557973 NM_001349182 9 - 5656 NP_001336111 32 292 - 2020 32557973 NM_001349183 9 - 5632 NP_001336112 32 292 - 2020 32557973

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell null (stem cell)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	zinc finger C3H C4 type
	a TM domain having at least two independent roles, membrane localization and E3 ligase activation, to regulate its physiological function

HOMOLOGY

Homologene

FAMILY	RNF144 family
	RING-in-between-RING family of E3 ubiquitin ligases

CATEGORY

enzyme , transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,nucleus
text	is mainly localized in the cytoplasmic vesicles and plasma membrane

basic FUNCTION	RNF144A, an E3 ubiquitin ligase for DNA-dependent protein kinase catalytic subunit (DNA-PKcs), can promote DNA damage-induced cell apoptosis
	RNF144A may be involved in TP53-mediated apoptosis through down-regulation of DNA-PKcs when cells suffer from persistent or severe DNA damage insults
	RNF144A promotes EGFR ubiquitination, maintains EGFR protein, and prolongs EGF/EGFR signaling during EGF stimulation
	functions as a tumor suppressor in breast cancer
	role for RNF144A in suppression of breast cancer growth and metastasis, and RNF144A is likely the first E3 ubiquitin ligase for HSPA2 in human cancer
	VRK3 protects cells by suppressing oxidative stress-induced ERK, and RNF144A sensitively regulates this process

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ZDHHC18 and ZDHHC23 competitively interact with a BMI1 E3 ligase, RNF144A, to regulate the polyubiquitination and accumulation of BMI1
	RNF144A interacted with and targeted HSPA2, a putative oncoprotein that is frequently upregulated in human cancer and promotes tumor growth and progression, for ubiquitination and degradation
	under oxidative stress, VRK3 migrates from the nucleus to the cytoplasm, which increases its chance of interacting with RNF144A, thereby promoting the degradation of VRK3

cell & other

REGULATION

induced by

DNA damage that induces RNF144A expression in a TP53-dependent manner

Other

important regulation of RNF144A through its transmembrane (TM) domain

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS