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FLASH GENE
Symbol MAP4K5 contributors: npt - updated : 05-12-2007
HGNC name mitogen-activated protein kinase kinase kinase kinase 5
HGNC id 6867
Location 14q13.2-q21      Physical location : 50.885.246 - 50.999.376
Synonym name
  • germinal center kinase-related
  • MEK kinase kinase 5
  • kinase homologous to SPS1/STE20
    • Synonym symbol(s) KHS, GCKR, KHS1, MAPKKKK5
    EC.number 2.7.1.11
    DNA
    TYPE functioning gene
    STRUCTURE 114.13 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D14S70 - D14S75 - D14S1039 - D14S259 - MAP4K5 - D14S269 - D14S978 - D14S281 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4373 95 846 - -
    - - 4421 95 846 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Ste20 family
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • MAP kinase kinase kinase kinase 5, activating in N terminal kinase
  • potentially involved in the stress response of fibroblast
  • activation of JUN kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS