SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,nucleus,nucleoplasm
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basic FUNCTION
| endoglyosidase cleaving heparan sulfate proteoglycan at a limited mumber of sites along the polysaccharide chain |
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essential in the disassembly of the extracellular matrix (ECM) by invading cells |
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cleaves heparan sulfate in the extracellular matrix (ECM) and hence participates in ECM degradation and remodeling |
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involved in glycosaminoglycan chain synthesis or modifications |
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significant involvement of heparanase in diabetic complications |
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helps drive exosome secretion, alters exosome composition, and facilitates production of exosomes that impact both tumor and host cell behavior, thereby promoting tumor progression |
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only known mammalian endoglycosidase capable of degrading heparan sulfate glycosaminoglycan, both in extracellular space and within the cells |
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important for palate formation because it mediated degradation of the ECM (extracellular matrix) of palatal shelves |
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involved in mechanisms of metastatic tumor cell migration. |
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role for heparanase in inflammatory cell trafficking that appears to require enzymatic activity |
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is a key player in renal fibrosis since it interacts with the regulation and the effects of TGFB1 |
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plays a central role in processes of placentation |
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is a modulator of the SDC1-SDCBP-PDCD6IP pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans |
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dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action |
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predominant enzyme in mammals capable of cleaving heparan sulfate, an activity highly implicated in cellular invasion and tumor metastasis |
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role for heparanase in modulating autophagy in normal and malignant cells, thereby conferring growth advantages as well as resistance to chemotherapy |