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FLASH GENE
Symbol GALNT6 contributors: mct - updated : 10-06-2011
HGNC name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
HGNC id 4128
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a hydrophobic anchor sequence near the N terminus
  • a stem region
  • a lumenal catalytic domain
  • a GT1 motif and Ga1/Ga1 NAc transferase motif
  • a C terminal ricin/lectin-like domain
  • a QXW lectin repeat
    • HOMOLOGY
    intraspecies homolog to GALNT3
    Homologene
    FAMILY
  • glycosyltransferase 2 family
  • GalNAc-T subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the initial step in O-linked (mucin type) oligosaccharide biosynthesis, possessing candidate for synthesis of onconfetal fibronectin
  • responsible for initiating mucin-type O-glycosylation
  • could glycosylate and stabilize an oncoprotein mucin 1 (MUC1), which was upregulated with GALNT6 in breast cancer specimens
  • glycosyltransferase involved in the initial step of O-glycosylation
  • GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    has transformational potentials through disruptive acinar morphogenesis and cellular changes similar to epithelial-to-mesenchymal transition in normal mammary epithelial cell, MCF10A (
    tumoral     --over  
    might contribute to mammary carcinogenesis through aberrant glycosylation and stabilization of MUC1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    screening of GALNT6 inhibitors would be valuable for the development of novel therapeutic modalities against breast cancer
    ANIMAL & CELL MODELS