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FLASH GENE

Symbol

GRM2

contributors: mct/npt - updated : 11-02-2013

HGNC name	glutamate receptor, metabotropic 2
HGNC id	4594

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in amyotrophic lateral sclerosis spinal cord constitutional     --low   in brain from untreated schizophrenic subjects constitutional     --over   in pyramidal neurons in the hippocampus of Alzheimer disease and often co-localizes with neurofibrillary pathology constitutional     --over   in schizophrenia, significantly higher levels of GRM2 mRNA in the prefrontal white matter

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry bipolar disorder   GRM2/GRM3 antagonists are promising targets for the discovery of novel antidepressants psychiatry schizophrenia   complex HTR2A/GRM2 is a promising new target for the treatment of psychosis

ANIMAL & CELL MODELS