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HGNC genecards Ensembl Unigene
FLASH GENE
Symbol NR1I3 last update : 17-01-2005
HGNC name nuclear receptor subfamily 1, group I, member 3
HGNC id 7969
Location 1q23.1
Synonym name constitutive androstane receptor-beta
Synonym symbol(s) CAR1, MB67, CAR-beta, CAR, , CAR-SV4, CAR-SV8, CAR-SV13, CAR-SV21
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNABack to top
TYPE functioning gene
STRUCTURE 8.00 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - DXS983 - DXS8079 - NR1I3 - PGK1 PGK1 - DXS1002 - DXS995 - qter
Authors Gene Map (98)
Physical map
CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
RNABack to top
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionauthors
- - - 2900 - - - Base
- - - 1400 - - - Base
EXPRESSION / SUBCELLULAR LOCALIZATIONBack to top
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Cardiovascularheart    
Digestiveliver   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
PROTEINBack to top
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding domain proximal P box followed by a ligand binding domain
  • short N terminal domain followed by the DNA binding and ligand binding/dimerization domains
  • C4 zinc finger domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies
     
    		 homolog to murine Nr1l3
    intraspecies
     
    Homologene
    FAMILY nuclear receptor subfamily 1, group I
    CATEGORY transcription factor , receptor nuclear
    basic FUNCTION
  • involved in the complex network of protein governing response to retinoic acid and its metabolites
  • playing an important role in the control of drug metabolism and disposition
  • regulating a number of genes encoding enzymes involved in xenobiotic/endobiotic metabolism, conjugation and transport of small hydrophobic substrates
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    androgen receptor
    a component putatively heterodimerizing with RXR(s)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by dexamethasone
    ASSOCIATED DISORDERSBack to top