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FLASH GENE
Symbol NRG2 contributors: - updated : 22-02-2006
HGNC name neuregulin 2
HGNC id 7998
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin domain
  • an EGF-like domain
  • a ser/thr rich domain
  • a transmembrane region (lacking in isoforms 5 and 6)
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus LOC291668
    homolog to murine LOC381149
    Homologene
    FAMILY epidermal growth factor (EGF) family
    CATEGORY regulatory , receptor membrane ligand ion channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text membrane-bound or soluble form
    basic FUNCTION
  • involved in growth and differentiation of epithelial, neuronal, glial and other cell types
  • ligand of Erb3/Erb4 receptor tyrosine kinase
  • recruits ERBB1 and ERBB2 and may promote the heterodimerization with the EGF receptor
  • promotes cell death of prostate cancer cells
  • may be a signal that regulates synaptic differentiation
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding directly to ERBB3 and ERBB4 and transactivating ERBB2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL5Q31.3
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate agents for suppression of tumor growth and metastasis
    Marker
    Therapy target
    ANIMAL & CELL MODELS