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FLASH GENE

Symbol

NRG2

contributors: - updated : 22-02-2006

HGNC name	neuregulin 2
HGNC id	7998

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous Schwann cell

cell lineage
cell lines	neuroblastoma
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	developing heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin domain
	an EGF-like domain
	a ser/thr rich domain
	a transmembrane region (lacking in isoforms 5 and 6)

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus LOC291668
	homolog to murine LOC381149

Homologene

FAMILY

epidermal growth factor (EGF) family

CATEGORY

regulatory , receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
text	membrane-bound or soluble form

basic FUNCTION	involved in growth and differentiation of epithelial, neuronal, glial and other cell types
	ligand of Erb3/Erb4 receptor tyrosine kinase
	recruits ERBB1 and ERBB2 and may promote the heterodimerization with the EGF receptor
	promotes cell death of prostate cancer cells
	may be a signal that regulates synaptic differentiation

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding directly to ERBB3 and ERBB4 and transactivating ERBB2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL5Q31.3

Susceptibility

Variant & Polymorphism

Candidate gene	candidate agents for suppression of tumor growth and metastasis
Marker
Therapy target

ANIMAL & CELL MODELS