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FLASH GENE
Symbol FZD10 contributors: mct - updated : 25-10-2012
HGNC name frizzled homolog 10 (Drosophila)
HGNC id 4039
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich domain
  • a FZ domain involved in binding with WNT ligands
  • seven transmembrane segments (7TM)
  • a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity gene 10
    Homologene
    FAMILY
  • Wnt signal receptor family
  • G protein coupled receptor superfamily
    • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • exhibiting characteristics of a WNT receptor
  • involved in signal transduction
  • may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
  • involved in carcinogenesis through activation of the beta-catenin - TCF signaling pathway synergistically with some class of WNTs
  • has a distinct role from other FZDs in canonical Wnt signal transduction
  • its transactivation causes the activation of the non-canonical Dvl-Rac1-JNK pathway and plays critical roles in the development/progression of synovial sarcomas (
  • potentially mediating WNT1 signalling to determine sensory neural differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary colorectal cancer
    tumoral       gain of function
    in synovial sarcoma and played critical roles in its cell survival and growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    promising candidate for molecular imaging and a target for therapy
    ANIMAL & CELL MODELS