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FLASH GENE

Symbol

FZD10

contributors: mct - updated : 25-10-2012

HGNC name	frizzled homolog 10 (Drosophila)
HGNC id	4039

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.28 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007197 1 - 3288 - 581 - 2002 11786918

EXPRESSION

Rna function	mRNAs expressed specifically in adult spiral ganglion neurons (
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Reproductive female system uterus cervix       female system ovary

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, kidney, lung, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal cysteine-rich domain
	a FZ domain involved in binding with WNT ligands
	seven transmembrane segments (7TM)
	a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif

HOMOLOGY

interspecies

homolog to Drosophila frizzled polarity gene 10

Homologene

FAMILY	Wnt signal receptor family
	G protein coupled receptor superfamily

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	exhibiting characteristics of a WNT receptor
	involved in signal transduction
	may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
	involved in carcinogenesis through activation of the beta-catenin - TCF signaling pathway synergistically with some class of WNTs
	has a distinct role from other FZDs in canonical Wnt signal transduction
	its transactivation causes the activation of the non-canonical Dvl-Rac1-JNK pathway and plays critical roles in the development/progression of synovial sarcomas (
	potentially mediating WNT1 signalling to determine sensory neural differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary colorectal cancer tumoral       gain of function in synovial sarcoma and played critical roles in its cell survival and growth

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon promising candidate for molecular imaging and a target for therapy

ANIMAL & CELL MODELS