Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCT5 contributors: mct/npt - updated : 19-05-2010
HGNC name chaperonin containing TCP1, subunit 5 (epsilon)
HGNC id 1618
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP1-ring complex (TRIC) and mediating ATP-dependent monomeric protein folding
  • cytosolic molecular chaperone implicated especially in the biogenesis of cytoskeletal proteins by promoting the correct folding of the major ubiquitous cytoskeletal components, tubulin and actin (Roobol 1995)
  • may be playing a role, in the folding of actin and tubulin
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PACRG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SNSP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS