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FLASH GENE
Symbol CCT5 contributors: mct/npt - updated : 19-05-2010
HGNC name chaperonin containing TCP1, subunit 5 (epsilon)
HGNC id 1618
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP1-ring complex (TRIC) and mediating ATP-dependent monomeric protein folding
  • cytosolic molecular chaperone implicated especially in the biogenesis of cytoskeletal proteins by promoting the correct folding of the major ubiquitous cytoskeletal components, tubulin and actin (Roobol 1995)
  • may be playing a role, in the folding of actin and tubulin
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PACRG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SNSP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS