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FLASH GENE
Symbol DBNL contributors: mct/npt - updated : 13-06-2015
HGNC name drebrin-like
HGNC id 2696
Location 7p13      Physical location : 44.084.238 - 44.101.313
Synonym name
  • SH3 domain-containing protein 7
  • hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa
  • cervical mucin-associated protein
  • drebrin-F
  • mammalian actin-binding protein 1
  • Synonym symbol(s) SH3P7, HIP-55, CMAP, ABP1, HIP55, mAbp1
    DNA
    TYPE like-sequence
    STRUCTURE 17.08 kb     13 Exon(s)
    MAPPING cloned Y linked N status tentative : very preliminary evidence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2213 - 431 - 1999 9891087
    13 - 2210 48 430 - 1999 9891087
    13 - 2237 - 439 - 1999 9891087
    11 - 2025 - 335 - 1999 9891087
    11 - 2041 - 327 - 1999 9891087
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiacmyocardium  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal actin depolymerization factor (ADF-H/C) domain
  • C-terminal SH3 domain bound a more distal proline-rich domain of SH3BP2
  • HOMOLOGY
    interspecies homolog to yeast Abp1p
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localizes to podosomes and is necessary for the formation of podosome rosettes in SRC-transformed fibroblasts
  • basic FUNCTION
  • actin-binding adaptor protein, interacting with and tyrosine phosphorylated by ZAP70, which is a crucial proximal protein tyrosine kinase for TCR signaling
  • is a novel molecular player in integrin biology that is critical for phagocytosis and firm neutrophil adhesion under flow conditions
  • DBNL and cortactin (CTTN) play distinct roles in podosome regulation
  • role in podosome rosette formation and cell invasion downstream of SRC
  • is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient polymorphonuclear neutrophils (PMN) extravasation during inflammation
  • F-actin-anchored COBL/DBNL complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells representing the source for all motor coordination in the cerebellar cortex
  • critical for organ development and immune response and is important for the regulation of the actin cytoskeleton through its interactions with F-actin and various cytoskeletal and cell signaling proteins
  • actin binding protein, negatively regulating myocardial contractility at the single-cell levels
  • multidomain adaptor protein that is critical for organ development and the immune response
  • is required for proper cell growth control
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to actin filaments, and activates HPK1 and c-Jun N-terminal kinase (JNK), which are two important lymphocyte signaling molecules
  • role for DBNL in growth factor-induced dorsal ruffle formation through its interaction with WIPF1
  • COBL-mediated dendritic branch induction in hippocampal neurons critically relied on DBNL
  • cell & other
    REGULATION
    Phosphorylated by the nonreceptor tyrosine kinase SYK that has a fundamental effect for several beta(2) integrin (CD11/CD18)-mediated neutrophil functions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer cell lines and in tumor tissues of lung cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS