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FLASH GENE

Symbol

ADAMTS5

contributors: mct - updated : 25-08-2016

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 5
HGNC id	221

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioblastoma cells constitutional     --low   required to inhibit aggrecan degradation in osteoarthritis cartilage constitutional     --low   during chondrogenesis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

adult Adamts5(-/-) mice are viable, they do not recover from developmental valve anomalies, but have myxomatous cardiac valves