motifs/domains
| a signal sequence |
|
a propeptide domain |
|
a reprolysin-type catalytic domain |
|
a zinc catalytic domain |
|
non-catalytic ancillary domains |
|
a disintegrin domain (Dis) |
|
a thrombospondin domain |
|
a cysteine-rich domain (Cysr) |
|
a spacer domain (Sp) |
|
a second thrombospondin domain follows the spacer domain |
|
one C terminal TSP-like module, that govern the specificity of the enzymes by modulating substrate binding |
|
CysR and Sp domains greatly increased its aggrecanolytic activity |
|
C-terminal domains affect the structure around the active site, favouring interaction with TIMP3  |
| basic FUNCTION
| cell surface adhesion protein cleaving the cartilage proteoglycan aggrecan, involved in the destruction of aggrecan in arthritic disease |
|
may play a role in glioma cell invasion through the cleavage of brevican |
|
major aggrecanase in cartilage metabolism and pathology |
|
(aggrecanolytic activity of ADAMTS5 was much greater than ADAMTS4) |
|
ADAMTS4 and ADAMTS5 not only play roles in the breakdown of cartilage extracellular matrix in osteoarthritis, but also mediate processing of matrilins in the secretory pathway |
|
in the growth plate ADAMTS5, and not ADAMTS4, has a physiological function in the intracellular processing of matrilins and potentially of other extracellular matrix proteins |
|
role of ADAMTS5 in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function |
|
a function of ADAMTS5 in dermal fibroblasts is potentially to maintain optimal versican content and pericellular matrix volume by continually trimming versican in hyaluronan-versican aggregates |
