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FLASH GENE
Symbol ADAMTS2 contributors: mct/npt - updated : 27-10-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 2
HGNC id 218
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • a propeptide domain
  • a reprolysin-type catalytic domain
  • a disintegrin-like domain
  • four thrombospondin type 1 (TSP1) module
  • a cysteine rich domain
  • a spacer domain without cysteine residues
  • terminal TSP-like modules
    • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Adamts2
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • a disintegrin-like and metalloprotease, cell surface adhesion protein, procollagen I/II aminopeptide processing enzyme
  • extracellular metalloproteinase responsible for cleaving the N-propeptides of procollagens I-III
  • cleaving the propeptides of type I and II collagen prior to fibril assembly and may be playing a role in development that is independent of its role in collagen biosynthesis
    • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    inhibited by TIMP3 (inhibit procollagen processing by cells)
    ASSOCIATED DISORDERS
    corresponding disease(s) EDS7C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS