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FLASH GENE
Symbol ACAA2 contributors: mct - updated : 30-08-2008
HGNC name acetyl-Coenzyme A acyltransferase 2
HGNC id 83
Location 18q21.1      Physical location : 47.309.874 - 47.340.251
Synonym name
  • acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
  • 3-ketoacyl-CoA thiolase, mitochondrial
  • beta ketothiolase
    • Synonym symbol(s) DSAEC, T1
    EC.number 2.3.1.16
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D18S460 - [D18S1118 - D18S470 ] - D18S474 - qter
    Authors Gene Map (98)
    Text [ACAA2 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1952 41 397 - Cao (2008)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a non-cleavable amino-terminal targeting signal
    • HOMOLOGY
    Homologene
    FAMILY
  • thiolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • acetyl-CoA acyltransferase 2, mitochondrial-3-oxoacyl-coenzyme A, thiolase, concluding the step of fatty acid beta oxidation
  • catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein functional BNIP3 binding partner (possible linkage between fatty acid metabolism and apoptosis of cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS