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FLASH GENE
Symbol AKAP10 contributors: mct - updated : 20-04-2013
HGNC name a kinase (PRKA) anchor protein 10
HGNC id 368
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two tandem regulator of G-protein signaling (RGS) domains, interacting with RAB11A and GTP-bound RAB4A
  • the C terminal R binding motifs
    • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to murine Akap10
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • a kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10 in the mitochondrial and/or the plasma membrane tethering the enzyme near its physiological substrate
  • regulates the morphology of the RAB11A-containing compartment, with co-expression causing accumulation of both proteins on enlarged endosomes
  • potentially promotes accumulation of recycling proteins in the RAB4A/RAB11A-positive endocytic recycling compartment
  • AKAP10 mediated prostaglandin E2 potentiation of the expression of cytokines IL10 and IL6, modulating Toll-like receptor signaling in alveolar macrophages
  • may play an important role in the development and progression of colorectal cancer
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with PDZK1 in renal proximal tubular cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to arrhythmias and sudden cardiac death
    Variant & Polymorphism other
  • AKAP10 Val allele may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS