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FLASH GENE
Symbol AKAP10 contributors: mct - updated : 20-04-2013
HGNC name a kinase (PRKA) anchor protein 10
HGNC id 368
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two tandem regulator of G-protein signaling (RGS) domains, interacting with RAB11A and GTP-bound RAB4A
  • the C terminal R binding motifs
    • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to murine Akap10
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • a kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10 in the mitochondrial and/or the plasma membrane tethering the enzyme near its physiological substrate
  • regulates the morphology of the RAB11A-containing compartment, with co-expression causing accumulation of both proteins on enlarged endosomes
  • potentially promotes accumulation of recycling proteins in the RAB4A/RAB11A-positive endocytic recycling compartment
  • AKAP10 mediated prostaglandin E2 potentiation of the expression of cytokines IL10 and IL6, modulating Toll-like receptor signaling in alveolar macrophages
  • may play an important role in the development and progression of colorectal cancer
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with PDZK1 in renal proximal tubular cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to arrhythmias and sudden cardiac death
    Variant & Polymorphism other
  • AKAP10 Val allele may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS