Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

AKAP10

contributors: mct - updated : 20-04-2013

HGNC name	a kinase (PRKA) anchor protein 10
HGNC id	368

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007202 15 - 3941 NP_009133 - 662 - 2009 19797056

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two tandem regulator of G-protein signaling (RGS) domains, interacting with RAB11A and GTP-bound RAB4A
	the C terminal R binding motifs

secondary structure

an amphipathic helix binding domain

HOMOLOGY

interspecies

homolog to murine Akap10

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,cytosolic

basic FUNCTION	a kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10 in the mitochondrial and/or the plasma membrane tethering the enzyme near its physiological substrate
	regulates the morphology of the RAB11A-containing compartment, with co-expression causing accumulation of both proteins on enlarged endosomes
	potentially promotes accumulation of recycling proteins in the RAB4A/RAB11A-positive endocytic recycling compartment
	AKAP10 mediated prostaglandin E2 potentiation of the expression of cytokines IL10 and IL6, modulating Toll-like receptor signaling in alveolar macrophages
	may play an important role in the development and progression of colorectal cancer

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with PDZK1 in renal proximal tubular cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to arrhythmias and sudden cardiac death

Variant & Polymorphism other	AKAP10 Val allele may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS