Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FAU contributors: mct - updated : 09-04-2020
HGNC name Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30
HGNC id 3597
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
fusion protein consisting of the ubiquitin-like protein fubi (74 AA and 7.8 kDa) at the N terminus and ribosomal protein S30 ( 59 AA and 6.6 kDa) at the C terminus
HOMOLOGY
interspecies homolog to viral FOX/FBR-MuSV
ortholog to murine Fau
homolog to rattus Rn.5998
homolog to zebrafish Dr.1455
homolog to C.elegans C26F1.4
Homologene
FAMILY
  • ubiquitin-like family
  • S30E family of ribosomal proteins
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • fusion protein consisting of a ubiquitin-like segment (Ubi-L) and ribosomal protein S30
  • displays tumour suppressor and oncogenic properties in different contexts
  • might be implicated in the macrophage response to lipopolysaccharide
  • FAU, BCLG and MELK, are crucially important in breast cancer
  • role for FAU in the regulation of platinum-resistance in ovarian cancer
  • covalently conjugates to SH3GL1, a member of the endophilin A family, and inhibits phagocytosis by macrophages
  • apoptosis-enhancing effect of FAU-BCL2L14 is due in part to down-regulation of PTGS2 activation in macrophages
  • negatively regulates T cell function
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 40S subunit of the cytoplasmic ribosome (ribosomal protein S30)
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • FAU modifies apoptosis-controller BCL2L14, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK)
  • post-translational modification of SH3GL1 by FAU might be implicated in phagocytosis by macrophages
  • pro-apoptotic activity of the FAU/BCL2L14 pathway offers an attractive explanation for the putative tumour suppressor role of FAU
  • FAU covalently binds to intracellular pro-apoptotic protein BCL2L14 and regulates apoptosis in macrophages
  • FAU knockdown increased the plasma membrane targeting and function of F508del-CFTR, but not of wild-type CFTR
  • HSPD1 negatively regulates the biological functions of ubiquitin-like protein FAU in macrophages
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulated expression of FAU and MELK is associated with poor prognosis in breast cancer
    tumoral     --low  
    in human breast, prostate and ovarian tumours
    Susceptibility to Recurrent pregnancy loss (RPL)
    Variant & Polymorphism SNP
  • FAU rs769440&
    • 8201;G allele had higher frequencies in patients with RP
    Candidate gene
    Marker
  • attractive target for improvements in breast cancer risk prediction and prognosis
    • Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    may offer a therapeutically relevant panel of drug targets to correct basic defects in F508del-CFTR processing
    cancerreproductivebreast
    attractive target for improvements in breast cancer therapy
    ANIMAL & CELL MODELS