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FLASH GENE

Symbol

FAU

contributors: mct - updated : 09-04-2020

HGNC name	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30
HGNC id	3597

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001997 5 - 579 - 133 - 2004 15543234

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

fusion protein consisting of the ubiquitin-like protein fubi (74 AA and 7.8 kDa) at the N terminus and ribosomal protein S30 ( 59 AA and 6.6 kDa) at the C terminus

HOMOLOGY

interspecies	homolog to viral FOX/FBR-MuSV
	ortholog to murine Fau
	homolog to rattus Rn.5998
	homolog to zebrafish Dr.1455
	homolog to C.elegans C26F1.4

Homologene

FAMILY	ubiquitin-like family
	S30E family of ribosomal proteins

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	fusion protein consisting of a ubiquitin-like segment (Ubi-L) and ribosomal protein S30
	displays tumour suppressor and oncogenic properties in different contexts
	might be implicated in the macrophage response to lipopolysaccharide
	FAU, BCLG and MELK, are crucially important in breast cancer
	role for FAU in the regulation of platinum-resistance in ovarian cancer
	covalently conjugates to SH3GL1, a member of the endophilin A family, and inhibits phagocytosis by macrophages
	apoptosis-enhancing effect of FAU-BCL2L14 is due in part to down-regulation of PTGS2 activation in macrophages
	negatively regulates T cell function

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the 40S subunit of the cytoplasmic ribosome (ribosomal protein S30)
	CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival

INTERACTION

DNA

RNA

binding

small molecule

protein	FAU modifies apoptosis-controller BCL2L14, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK)
	post-translational modification of SH3GL1 by FAU might be implicated in phagocytosis by macrophages
	pro-apoptotic activity of the FAU/BCL2L14 pathway offers an attractive explanation for the putative tumour suppressor role of FAU
	FAU covalently binds to intracellular pro-apoptotic protein BCL2L14 and regulates apoptosis in macrophages
	FAU knockdown increased the plasma membrane targeting and function of F508del-CFTR, but not of wild-type CFTR
	HSPD1 negatively regulates the biological functions of ubiquitin-like protein FAU in macrophages

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulated expression of FAU and MELK is associated with poor prognosis in breast cancer tumoral     --low   in human breast, prostate and ovarian tumours

Susceptibility

to Recurrent pregnancy loss (RPL)

Variant & Polymorphism SNP	FAU rs769440&
	8201;G allele had higher frequencies in patients with RP

Candidate gene
Marker	attractive target for improvements in breast cancer risk prediction and prognosis
Therapy target
	System Type Disorder Pubmed respiratory CF (mucoviscidosis)   may offer a therapeutically relevant panel of drug targets to correct basic defects in F508del-CFTR processing cancer reproductive breast attractive target for improvements in breast cancer therapy

ANIMAL & CELL MODELS