protein
| protein phosphatase 2B, PP2Bbeta and calcineurin, CaN |
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calmodulin with high affinity in a Ca2+-dependent manner |
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potassium inwardly-rectifying channel, subfamily J, member 2, KCNJ2 |
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beta1 and beta3 of GABA(A) receptor |
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IQ motif containing GTPase activating protein 1, IQGAP1 |
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interacts with ADCY8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal system |
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interacts with KCND2 complexes and the two proteins colocalize in hippocampal neurons |
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binding of Ca2+/CALM1 to AKAP5 generates an additional PP2B interaction site on the anchoring protein to activate the tethered phosphatase |
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CALM1 associated with AKAP5 is able to activate anchored PP2B within the same signaling complex |
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novel PPP1 regulatory subunit |
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directly bind to adenylyl cyclase type 8 (ADCY8) and regulate its responsiveness to store-operated Ca2+ entry (SOCE) |
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CALM1 is a known interaction partner of AKAP5 that has been shown to regulate activity of the kinase PKC in a Ca(2+) -dependent manner |
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AKAP5 can interact with CABP1, a neuronal calcium-binding protein implicated in regulation of Ca(2+) -influx and release |
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direct anchoring of both PRKACA and ADCY1 to TRPV1 by AKAP5 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia |
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anchoring of not only PRKACA but also ADCY1 by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA receptor activity |
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the extreme C-terminus of ADRB1 binds DLG1 and AKAP5 to organize a scaffold involved in trafficking of the ADRB1 |
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a key region on AKAP79, between AAs 326-336, is responsible for its interaction with TRPV1 |
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GPER1 interacted with membrane-associated guanylate kinases, including DLG1 and DLG4, and protein kinase A-anchoring protein (AKAP5) in the plasma membrane in a PDZ-dependent manner |