Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GADD45B

contributors: shn/mct - updated : 04-01-2015

HGNC name	growth arrest and DNA-damage-inducible, beta
HGNC id	4096

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   significantly in patients with hypertrophy cardiomyopathy tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma cardiac its inhibition might be of benefit in the treatment of acute ischaemic heart disease

ANIMAL & CELL MODELS

	Mice with Gadd45b deletion exhibit specific deficits in neural activity–induced proliferation of neural progenitors and dendritic growth of newborn neurons in the adult hippocampus (Ma et al 2009)
	hypertrophic zone of the Gadd45beta(-/-)mouse embryonic growth plate is compressed, and expression of type X collagen (Col10a1) genes is decreased