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FLASH GENE

Symbol

CAMKK2

contributors: mct - updated : 08-03-2023

HGNC name	calcium/calmodulin-dependent protein kinase kinase 2, beta
HGNC id	1470

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer and leads to progression tumoral       gain of function in hepatocellular carcinoma (HCC) and negatively correlated with HCC patient survival

Susceptibility

to bipolar and psychiatric disorders

Variant & Polymorphism SNP	Single-Nucleotide Polymorphisms increasing the risk of bipolar and psychiatric disorders

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive   novel therapeutic target for sex hormone-regulated cancers neuromuscular myopathy   CAMKK2 could serve as a potential target to treat patients with muscle injury or myopathies cancer digestive stomach CAMKK2 as a novel therapeutic target in gastric cancer cancer digestive liver CaMKK2 and CaMK4 may represent potential targets for hepatic cancer diabete     CaMKK2 may be an attractive therapeutic target for combatting comorbidities associated with perturbed insulin signaling

ANIMAL & CELL MODELS

CaMKK2 null mice have increased adiposity and larger adipocytes than do wild-type mice, whereas energy balance is unchanged