Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAN1A1 contributors: mlc - updated : 26-10-2007
HGNC name mannosidase, alpha, class 1A, member 1
HGNC id 6821
Location 6q22      Physical location : 119.499.266 - 119.670.926
Synonym name
  • Man9-mannosidase
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
  • Synonym symbol(s) HUMM3, HUMM9, MAN9
    EC.number 3.2.1.113
    DNA
    TYPE like-sequence
    STRUCTURE 171.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D6S266 - D6S261 - AMD1 - D6S303 - D6S287 - PLN - D6S304 - qter
    Authors Gene Map (98)
    Physical map
    RWDD1 6q13-q22.33 RWD domain containing 1 RSHL3 6q22.31 radial spokehead-like 3 C6orf113 6q22.31 chromosome 6 open reading frame 113 KPNA5 6q22.31 karyopherin alpha 5 (importin alpha 6) C6orf189 6q22.31 chromosome 6 open reading frame 189 GPRC6A 6q22.31 G protein-coupled receptor, family C, group 6, member A RFXDC1 6q22.31 regulatory factor X domain containing 1 VGLL2 6q22.31 vestigial like 2 (Drosophila) ROS1 6q21-q22 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) DCBLD1 6q22.31 discoidin, CUB and LCCL domain containing 1 GOPC 6q21 golgi associated PDZ and coiled-coil motif containing LOC221308 6q22.31 similar to RIKEN cDNA 5730521E12 C6orf68 6q22.31 chromosome 6 open reading frame 68 SLC35F1 6q22.31 solute carrier family 35, member F1 LOC391965 6 hypothetical gene supported by BX647084 BP75 6q22.1-q22.33 hypothetical gene supported by BX647084 PLN 6q22.1 phospholamban psiSSX10 6q22 SSX10 pseudogene C6orf61 6q22.31 chromosome 6 open reading frame 61 ASF1A 6q22.32 ASF1 anti-silencing function 1 homolog A (S. cerevisiae) MCMDC1 6q22.31 minichromosome maintenance deficient domain containing 1 C6orf60 6q22.31 chromosome 6 open reading frame 60 MAN1A1 6q22 mannosidase, alpha, class 1A, member 1 C6orf170 6q22.32 chromosome 6 open reading frame 170 GJA1 6q22.3 gap junction protein, alpha 1, 43kDa (connexin 43) LOC260339 6q22.32 processed pseudogene mtTFA 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4139 - 653 - Breuza (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Hearing/Equilibriumear   highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic tail
  • a single transmembrane segment (TM1)
  • a large C-terminal catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • mannosyl-oligo saccharide alpha-1,2-mannosidase, membrane type
  • involved in processing of Asn-linked (N) glycans
  • trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS