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FLASH GENE

Symbol

PIM2

contributors: mct - updated : 06-03-2015

HGNC name	pim-2 oncogene
HGNC id	8987

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in multiple B-cell lymphoma types, associated with an aggressive clinical course tumoral     --over   in Prostate cancer cell lines and tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   PIM2 kinase inhibition is a rational approach in DLBCL treatment cancer hemopathy   new target for multiple myeloma treatment cancer reproductive breast PIM2-USP27X-MYC signaling axis is a new potential target for breast cancer treatment

ANIMAL & CELL MODELS

compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes