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FLASH GENE
Symbol PTPRT contributors: mct/npt - updated : 18-11-2014
HGNC name protein tyrosine phosphatase, receptor type, T
HGNC id 9682
DNA
TYPE functioning gene
STRUCTURE 1117.16 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D20S99 - D20S170 - TOP1 - PLCG1 - D20S858 - PTPRT - D20S108 - D20S96 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 12701 - 1460 - 2009 19816407
contains an extra internal segment
31 - 12644 - 1441 - 2009 19816407
lacks an internal segment
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal MAM domain
  • three Ig-like domain
  • nine fibronectin type III repeats
  • a single transmembrane segment (TM1)
  • a large juxtamembrane segment
  • two cytoplasmic phosphatase domains
    • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 2B subfamily
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text delineating with FGF1, a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex
    basic FUNCTION
  • tyrosine phosphatase receptor controlling motor axon guidance
  • brain-specific protein that regulates synapse formation through interaction with cell adhesion molecules (Lim 2009)
  • tumor suppressor function
  • regulate the fusion of synaptic vesicle through dephosphorylation
  • regulate synaptic formation and development of hippocampal neurons
  • appears to control the activity of STXBP1 in formation of SNARE complexes during fusion of synaptic vesicles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FYN (its function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase FYN) (Lim 2009)
  • interacting with PXN (specifically regulates paxillin phosphorylation at tyrosine residue 88 (Y88) in colorectal cancer (CRC) cells)(Zhao 2010)
  • function of the BCR GTPase-activating domain could be modulated by protein tyrosine phosphatase receptor T (PTPRT), which is expressed principally in the brain
  • could regulate the interaction of STXBP1 with STX1A, and as a result, the synaptic vesicle fusion appeared to be controlled through dephosphorylation of STXBP1
  • PTPRT-modulated STAT3 signaling implicated in the regulation of high-fat diet-induced obesity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    tumoral somatic mutation      
    in colon carcinomas and gastric carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • (Ptprt) knockout mice are resistant to high-fat diet-induced obesity