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FLASH GENE

Symbol

RAB31

contributors: mct - updated : 11-04-2012

HGNC name	RAB31, member RAS oncogene family
HGNC id	9771

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	154.32 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D18S459 - D18S52 - D18S1132 - D18S62 - D18S471 - D18S1163 - PTPRM - D18S464 - D18S1158 - RAB31 - D18S482 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006868 7 - 4009 NP_006859 21.6 195 - 1996 8863739 minor - - 900 - 194 testis, ovary, lung and leukocytes, highly 1996 8863739

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately   vessel       moderately Digestive mouth       moderately   pancreas exocrine       moderately Endocrine adrenal gland       moderately Reproductive female system uterus cervix   highly Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     moderately Connective bone     highly

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP

HOMOLOGY

interspecies	homolog to rattus Rab31 (94.4 pc)
	homolog to murine Rab31 (94.3 pc)

Homologene

FAMILY	small GTPase superfamily
	Rab family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytoskeleton,microtubule
text	lipid-anchor
	cytoplasmic side
	colocalizes with TGN markers, early endosomes, and microtubules
	localizes in the trans-Golgi network (TGN) and endosomes

basic FUNCTION	acting as a GTPase
	mediated signal transduction
	involved in trafficking at trans-Golgi network
	required for transport of mannose-6-phosphate receptors from trans-Golgi network (TGN) to endosomes and for the Golgi/TGN organization
	Rab protein specifically expressed in the astroglia lineage and may have a role in regulating EGFR trafficking in some cell types
	involved in the trafficking of early endosomes
	small GTPase that is localized on early endosomes and regulates early endosomal sorting
	early endosomal Rab GTPase as a positive regulator of NGF signal transduction and cell differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport , endocytosis transport

text	vesicular transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	RIN3 specifically acts as a GEF for RAB31
	RAB5A and RAB31 directly interact with NGFR primarily via helix 4 of the NGFR death domain

cell & other

REGULATION

Other

prenylated

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS