SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,centromere
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| highly in the nuclear fraction |
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basement membrane (secretory form) |
basic FUNCTION
| basement membrane protein, enabling proper |
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chromosome segregation |
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playing a role in the interaction of chromosomes with the ATPase motor protein (KIFAP3) |
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complexing with small G protein GDP dissociation |
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stimulator (SMAP/KAP3) and a ATPase motor associated protein KIF3A/B |
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required to prevent fragile site expression |
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post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein |
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play an important role in the maintenance of chromosomal integrity by preventing the premature separation of the sister chromatids at the onset of anaphase |
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important component of DNA repair (ATM- and ATR-dependent phosphorylation of SMC1A and SMC3 are critical for DNA damage response) |
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dynamics of cohesins REC8, STAG3, SMC1B and SMC3 suggest their participation in sister chromatid cohesion throughout the whole meiotic process in human oocytes |
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is radially displaced from the spindle axis and confines pericentric chromatin |
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pericentric SMC3 and SMC4 contribute to spindle length regulation and dynamics in metaphase |
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regulates sister chromatid cohesion and also plays a role in transcriptional control of gene expression |
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multiunit complex of SMC1A, SMC3 and RAD21, associates with chromatin after mitosis and holds sister chromatids together following DNA replication |
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STAG2, RAD21, SMC1A, SMC3 mutations participate in leukemogenesis through the deregulated expression of genes that are involved in myeloid development and differentiation |
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cohesin ring is a protein complex composed of four core subunits: SMC1A, SMC3, RAD21 and STAG1/STAG2 and is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation |
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NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes codify for the "cohesin complex" playing a role in chromatid adhesion, DNA repair and gene expression regulation |