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FLASH GENE
Symbol GTF2F1 contributors: mct - updated : 10-10-2012
HGNC name general transcription factor IIF, polypeptide 1, 74kDa
HGNC id 4652
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central charged cluster domain (binding to SRF's activation domain)
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Co1f1.1
    Homologene
    FAMILY
  • TFIIF alpha subunit family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB
  • it promotes transcription elongation
  • increasing the average rate of RNA chain elongation across DNA templates
  • required for transcriptional initiation by RNA polymerase II
  • supports elongation and suppresses pausing by stabilizing the post-translocated elongation complex, in collaboration with TCEA1 (TCEA1 has a role in suppression of transient pausing)
  • with POLR2G are involved in both early and late transcriptional stages (Cojocaru 2008)
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
  • subunit of RNA polymerase II transcription initiation factor II F
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Mg2+
    • protein
  • RNA polymerase II, SRF (serum response factor)
  • interacts with GTF2F2 and CTDP1
  • has an important role in stabilizing GTF2B within the preinitiation complex and after transcription initiates
  • importance of GTF2F1 in stabilizing GTF2B interaction with the transcription complex, and potentially GTF2F1 should also participate in the process of elongation termination
  • POLR2M stabilizes poised polymerases while maintaining their responsiveness to CCNT1, suggesting that Mediator overcomes a POLR2M-mediated block of initiation by allowing GTF2F1 function
  • POLR2M competes with GTF2F1 for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of GTF2F1 in preinitiation complex assembly
    • cell & other
    REGULATION
    Other critical target for SRF-activated transcription
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS